Valif ( Vardenafil )

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Common use

This is a powerful medicine to treat erectile dysfunctions. It works only if there is sexual stimulation. Sexual arousal releases nitric oxide from the nerves' endings of the cavernous bodies of the penis and activates guanylate cyclase enzyme. Guanylate cyclase in its turn is responsible for production of cyclic guanosine monophosphate (cGMP). Due to cGMP the blood vessels supplying the penis with blood widen and relax. Valif prevents phosphodiesterase-5 enzyme from destroying cGMP and in this way helps to support blood flow to the penis.



Dosage and direction

The recommended dose of Valif contains 20 mg of Vardenafil, it is available in a pack of sachet. Take it an hour before intercourse. In case of adverse effects it is recommended to reduce the dose to 5 mg daily. Do not exceed the recommended dose. Strictly follow all recommendations of your doctor and never take the drug if it was not prescribed to you.


Precautions

Valif is not recommended in patients who have a stroke or heart failure, or a heart attack in history and especially within last six month. Before using Valif inform your doctor if you have serious renal impairment, a bleeding disorder, stomach ulcerations, or an inherited retinal disorder such as retinitis pigmentosa, allergic reaction to this medicine or any other medicines, deformation of the penis such as angulation, cavernous fibrosis (Peyronie's disease), as well as in diseases that contribute to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, or leukemia).


Contraindications

Valif cannot be prescribed in patients who are hypersensitive to its ingredients, ones treated with organic nitrates. Use in individuals who have not reached the age of 16 y.o. is contraindicated. Concomitant use of HIV protease inhibitors such as indinavir and ritonavir with Valif is prohibited.


Possible side effect

Treatment with Valif usually does not lead to serious side effects and if any they are mostly transient. The most frequent side effects are: headache, flushing (hyperemia of the person), dizziness, diarrhea, nausea, stuffy nose. More rare and uncommon adverse effects are photosensitivity of skin, hypertension, back pain, watery eyes, hypotension, myalgia, priapism.


Drug interaction

Metabolism of Valif is inhibited by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Valif also reduces the blood concentration of ritonavir and indinavir. Chest pain may become more acute in patients treated with nitrates as the medication increases heart rate and lowers blood pressure. Valif is able to exaggerate the blood pressure lowering effects of alpha-blocking drugs (terazosin or Hytrin). Valif never should be administered in patients who are treated with organic nitrates.



Missed dose

Valif is taken when needed but not more often than once daily so missed dose is not supposed.


Overdose

Symptoms of overdose include pain in the back, jaw, arm, chest, blindness, blurred or decreased vision, or discomfort.


Storage

Store at room temperature out of reach of children and pets, away from moisture and sunlight.


Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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